ABSTRACT
The tail suspension test (TST) is a valid tool for assessing antidepressant activity. Association between depression and lower locomotion and exploration activities is also reported. In the present study, photoactometer, hole board and elevated plus maze tests were performed to evaluate locomotion, exploration and anxiety activities on animals of first and second set, however animals of second set were pre-exposed to TST. The comparison between these two sets will help in understanding the impact of pre-exposure to TST on behavioural parameters. In both sets, swiss albino mice were treated with caffeine (10 mg/kg, ip), bupropion (10 mg/kg, ip), duloxetine (10 mg/kg, ip), nicotine (0.8 mg/kg, sc) and normal saline. Control group of second set showed significant decrease in locomotion, exploration and increase in anxiety when compared against control group of first set. In second set, duloxetine, bupropion, and nicotine treated groups showed significant increase in locomotion when compared against control group of same set. Overall, pre-exposure to TST leads to significant decrease in locomotion, exploration activities and increase in anxiety level. Further studies demonstrating it’s time bound impact on brain monoamine levels with correlation to behavioural paradigms may help to validate these outcomes.